Repeated central administration of selegiline attenuated morphine physical dependence in rat
نویسندگان
چکیده
منابع مشابه
Repeated central administration of selegiline attenuated morphine physical dependence in rat.
BACKGROUND Long-term exposure to opiates induces physical dependence; however, the neurobiological mechanisms of this phenomenon are not completely clear. The purpose of this study was to evaluate the effects of systemic and intracerebroventricular (icv) administration of selegiline (a selective inhibitor of monoamine oxidase B) on the morphine withdrawal syndrome in rats. METHODS To this aim...
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Background: Chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. The aim of this study is the assessment of systemic and intracerebroventricular (icv) administration of ramelteon (a melatonin receptor agonist) on morphine physical dependence. Methods: 88 adult male rats were divided into 2 major groups, namely “systematic” and ...
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متن کاملAttenuation of Morphine Physical Dependence and Blood Levels of Cortisol by Central and Systemic Administration of Ramelteon in Rat
BACKGROUND Chronic administration of morphine cause physical dependence but the exact mechanism of this phenomenon remains unclear. The aim of this study is the assessment of systemic and intracerebroventricular (icv) administration of ramelteon (a melatonin receptor agonist) on morphine physical dependence. METHODS 88 adult male rats were divided into 2 major groups, namely "systematic" and ...
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ژورنال
عنوان ژورنال: Pharmacological Reports
سال: 2013
ISSN: 1734-1140
DOI: 10.1016/s1734-1140(13)71036-3